Abstract. A holy grail of hydrology is to understand catchment processes well enough that models can provide detailed simulations across a variety of hydrologic settings at multiple spatiotemporal scales, and under changing environmental conditions. Clearly, this cannot be achieved only through intensive place-based investigation at a small number of heavily instrumented catchments, or by empirical methods that do not fully exploit our understanding of hydrology. In this opinion paper, we discuss the need to actively promote and pursue the use of a "large catchment sample" approach to modeling the rainfall–runoff process, thereby balancing depth with breadth. We examine the history of such investigations, discuss the benefits (improved process understanding resulting in robustness of prediction at ungauged locations and under change), examine some practical challenges to implementation and, finally, provide perspectives on issues that need to be taken into account as we move forward. Ultimately, our objective is to provoke further discussion and participation, and to promote a potentially important theme for the upcoming Scientific Decade of the International Association of Hydrological Sciences entitled Panta Rhei.