Abstract. Plastic film mulching (PFM) has widely been used around the world to save water and improve crop yield. However, the effect of PFM on soil respiration (R_s) remains unclear and could be further confounded by irrigation and precipitation. To address these topics, controlled experiments were conducted in mulched and non-mulched fields under drip irrigation from 2014 to 2016 in an arid area of the Xinjiang Uygur Autonomous Region, northwest China. The spatio-temporal pattern of soil surface CO₂ flux as an index of soil respiration under drip irrigation with PFM was investigated, and the confounded effects of PFM and irrigation/precipitation on soil respiration were explored. The main findings were as follows. (1) Furrows, planting holes, and plastic mulch are three important pathways of soil CO₂ emissions in mulched fields, of which the planting hole efflux outweighs that from the furrow, with the largest values of 8.0 and 6.6 µmol m⁻² s⁻¹, respectively, and the plastic mulch itself can emit up to 3.6 µmol m⁻² s⁻¹ of CO₂. (2) The frequent application of water (i.e. through irrigation and precipitation) elevates soil moisture and soil respiration and enhances their variation. The resultant higher variation of soil moisture further alleviates the sensitivity of soil respiration to soil temperature, leading to a weak correlation and lower Q₁₀ values. (3) Soil CO₂ effluxes from furrows and ridges in mulched fields outweigh the corresponding values in non-mulched fields in arid areas. However, this outweighing relation attenuates with increasing precipitation. Furthermore, by combining our results with those from the literature, we show that the difference in soil CO₂ effluxes between non-mulched and mulched fields presents a linear relation with the amount of precipitation, which results in negative values in arid areas and positive values in humid areas. Therefore, whether PFM increases soil respiration or not depends on the amount of precipitation during the crop-growing season.