To better understand how rain-on-snow (ROS) events affect snowpack outflow volumes and streamflow generation, we measured snowpack outflow volumes and isotopic composition during 10 ROS events with automated snowmelt lysimeters at three locations in a pre-Alpine catchment. We quantified the spatio-temporal variability of snowpack outflow and its relative contribution to streamflow, and identified rainfall characteristics and initial snow depth as major controls on snow hydrological processes.