A new quasi-3-D model was developed by coupling a soil water balance model with MODFLOW iteratively for regional-scale water flow modeling. The model was tested to be effective and efficient with well-maintained mass balance. A modeling framework was developed to organize the coupling scheme and to handle the pre- and post-processing information. The model is then used to evaluate groundwater recharge in a real-world application, which shows the model practicability in regional-scale problems.