Major critical points have emerged during the review process, as clearly stated by the constructive comments of the Reviewers, both reviewers being very critical on some key aspects. These, together with the replies proposed by the Authors suggest that the manuscript requires a set of major revisions prior to being considered again. It is not my intention to disregard any of the points raised by the Reviewers and it should be clear that there is no guarantee that the manuscript be accepted unless all of the Reviewers are unambiguously satisfied.

On the basis of the Reviewers comments and my own assessment I see no reason to delay publication of this study.